A review: Development of magnetic nano vectors for biomedical applications
1 PCSIR Laboratories Complex Ferozepur Road, Lahore, Pakistan.
2 PCSIR Head Office, Constitution Avenue, Islamabad, Pakistan.
3 Department of Chemistry, University of Lahore, Pakistan.
Review Article
GSC Advanced Research and Reviews, 2021, 08(02), 085–110.
Article DOI: 10.30574/gscarr.2021.8.2.0169
Publication history:
Received on 11 July 2021; revised on 19 August 2021; accepted on 21 August 2021
Abstract:
The study of magnetic nanoparticles (MNPs) is an emergent field of science in this era due to their widespread utilization in the various fields of biomedical science. Developing concerns of magnetic nanoparticles in the researcher’s field led to design a huge number of MNPs including individual or binary metallic particles, oxides, (ferrites), biopolymer coated composites, metallic carbides and graphene mediated nanoparticles. Numerous synthetic routes are defined in literature to attain the desired size, crystal structure, morphology and magnetic properties. To build up biocompatibility, MNPs subjected to surface treatments by coating with some suitable organic or inorganic biomaterials which not only improves its physical characteristics but also elevate its chemical stability. These biomaterials coat either isolatly or in a combined state to enhance the colloidal stability, magnetic properties as well as prevent it cytotoxicity and surface corrosion in the biological media. These properties are essential for the particles and empowering their effectiveness in various biomedical science i.e., drug delivery Magnetic resonance imaging (MRI), hyperthermia, biosensors and gene therapy etc. Current review recapitulates the verdicts of previous research on the subject of magnetic nanoparticles. It will also explain the recent advancements of biomaterials that execute a dynamic role in various medical treatments. Our main focus is to report the particle types, design and properties as well as discussing various synthetic routes including sol gel, co-precipitation, microemulsion, green synthesis, sonochemical method and polyol synthesis etc. These methods produced particles of excellent yield with unique magnetic properties, coercivity and crystallinity and enhanced biocompatibility as compared to traditional methods used to develop MNPs.
Keywords:
Biomaterials; Magnetic nanoparticles (MNPs); Biomedical Applications of MNPs; Magnetic resonance imaging (MRI); Drug carriers; Hyperthermia
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