Effect of alpha-cypermethrin on serotonin, nor-epinephrine and brain changes in rats

Hussein A Kaoud; Ahmed H Elsaied; Maged A Khalil

doi:10.30574/gscarr.2020.4.1.0060

Authors

Hussein A Kaoud Dept. of Veterinary Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt.
Ahmed H Elsaied Researcher in Dept. of Pharmaceuticals Biotechnology, Martin Luther King College, Germany. Email.
Maged A Khalil Researcher in Dept. of Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt.

DOI:

https://doi.org/10.30574/gscarr.2020.4.1.0060

Keywords:

Brain Damage, Alpha-Cypermethrin, Acute Sub-Lethal Dose, Serotonin, Nor-epinephrine

Abstract

In the present study, brain damages, serotonin and nor-epinephrine activity on rat brain were investigated. A single sub-acute lethal -oral dose of Alpha-Cypermethrin (25 mg kg ^-1) was given to rat. Blood and brain tissue samples were examined biologically and histopathologically at various times (1, 2, 3, 4 and24 h) after dosing. Results revealed that extracellular serotonin levels % (f mol/mg tissue) in rat ventral hippocampus at 25 mg kg^-1 B.W. After 1, 2, 3 and 24 hr. were 105±4, 80 ±7, 80 ±4, 70 ±4, respectively. While extracellular NA levels after 1, 2, 3 and 24 hr. were 300±10, 450 ±14, 400±12, 400±11, respectively. Alpha-cypermethrin acts as nor-epinephrine reuptake inhibitors (NRIs) and serotonin reuptake stimulator in rat brain. The lesions in the brain of the treated groups were gliosis, perineuronal vacuolation, perivascular vacuolation, and neuronal degeneration.

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References

Gotoh Y, Kawakami M, Matsumoto N and Okada Y. (1998). Permethrin emulsion ingestion: clinical manifestations and clearance of isomers. Clin. Toxicol, 36, 57–61.

He, JJ, Chen F, Liu, R, Song L, Chang HC and Wang XR. (2006). Fenvalerate-induced alterations in calcium homeostasis in rat ovary. Biomed. Environ. Sci, 19, 15–20.

Eells JT, Bandettini PA, Holman PA and Propp JM. (1992). Pyrethroid insecticide-induced alterations in mammalian synaptic membrane potential. J. Pharmacol. Exp. Ther, 262, 1173–1181.

Crofton KM and Reiter LW. (1987). Pyrethroid insecticides and the gamma-aminobutyric acid A receptor complex: Motor activity and the acoustic startle response in the rat. J. Pharmacol. Exp. Ther, 243, 946–954.

Lawrence LJ and Casida JE. (1983). Stereospecific action of pyrethroid insecticides on the 7-aminobutyric acid receptor-ionophore complex, Science, 221, 1399-1401.

Bloomquist JR, Adams PM and Soderlund DM. (1986). Inhibition of γ-aminobutyric acid-stimulated chloride flux in mouse brain vesicles by polychlorocycloalkane and pyrethroid insecticides. Neurotoxicology, 7(3), 11-20.

Vega SS. (1994). Note on the toxicity of pesticides used in tropical crops. Ciencias Ambientales., 11, 181.

Bloms-Funke P, Dremencov E, Cremers TIFH and Tzschentke TM. (2011). Tramadol increases extracellular levels of serotonin and noradrenalin as measured by in vivo microdialysis in the ventral hippocampus of freely moving rats, Neurosci Lett, 490(3), 191-5.

Karalliede L and Senanayake N. (1999). Organophosphate insecticide poisoning. J. Int. Fed. Clin. Chem, 11, 1.

SAS. (2000). (Statistical Analysis System, Version 9.2): SAS Institute Inc., Cary, NC 27513-2414 USA

Brown SK, Ames RG and Mengle DC. (1989). Occupational illness from cholinesterase inhibiting pesticides among agriculture pesticide applicators in California. Arch. Environ. Health, 44 (1), 34.

Anadón A, Martinez-LarraZaga MR and Díaz MJ. (1991b). Toxicokinetics of permethrin in the rat. Toxicol Appl Pharmacol, 110, 1-8.

Anadón A, Martinez-LarraZaga MR and Fernandez-Cruz ML. (1996). Toxicokinetics of deltamethrin and its 4'-HO-metabolite in the rat. Toxicol Appl Pharmacol, 141, 8-16.

(NASSAs). (2012). The mechanism of action of noradrenergic and specific serotonergic antidepressants. CNS forum.

Kaoud HA, Hellal MH, Farag MM, Sherein S, Ibtesam AE and Ashour H. (2013). Effects of Acute Sub-lethal Dose of Tramadol on α2-Adrnergic Receptors and Liver Histopathology in Rat. Global Journal of Current Research, 1(2), 70-76.

El-Toukhy MA and Girgis RS. (1993). In vivo and in vitro studies on the effect of larvin and cypermethrin on adenosine triphosphatase activity of male rats. J Environ Sci Health, B 28(5), 599-619.

Aldridge WN, Clothier B, Forshaw P, et al. (1978). The effect of DDT and pyrethroids cismethrin and decamethrin on the acetyl choline and cyclic nucleotide content of rat brain. Biochem Pharmacol., 27, 1703-1706.

Lock EA and Berry PN. (1981). Biochemical changes in the rat cerebellum following cypermethrin administration. Toxicol. Appl. Pharmacol, 59(3), 508–514.

Brodie ME and Aldridge WN. (1982). Elevated cerebellar cyclic GMP levels during the deltamethrin-induced motor syndrome, Neurobehav Toxicol Teratol, 4, 109-113.

Brodie ME and Opacka J. (1987). Dissociation between circling behaviour and striatal dopamine activity following unilateral deltamethrin administration of rats. Naun. Schmied. Arch. Pharmacol, 331(4), 341–346.

Llinas RR. (1982). Calcium in synaptic transmission. Sci. Am, 247(4), 56–65.

Khan A, Faridi HA, Ali M, Khan MZ, Siddique M, Hussain I and Ahmed M. (2009). Effects of cypermethrin on some clinico- hemato- biochemical and pathological parameters in male dwarf goats (Capra hircus). Exp Toxicol Pathol, 61, 151-60.

Manna S, Bhattacharya D, Basak DK and Mandal TK. (2004). Single oral dose toxicity study of á cypermethrin in rats. Indian J Pharmacol, 36, 25-8.

Luty S, Latuszynska J, Halliop J, Tochman A, Obu Chowska D, Prazylepa E and Korezak E. (1998). Toxicity of dermally applied alpha cypermethrin in rats. Ann Agric Environ Med, 5, 109-15.

Manna S, Bhattacharyya D, Mandal TK and Das S. (2004b). Repeated dose toxicity of alpha-cypermethrin in rats, J. Vet. Sci, 5(3), 241–245.

Grewal KK, Sandhu GS, Kaur RR, Brar RS and Sandhu HS. (2010). Toxic impact of cypermethrin on behaviour and histology of certain tissues of albino rats. Toxicol Intl, 17, 94-8.

Shailendra SK, Mishra J, Abbas S and Bandyopadhyay S. (2016). Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Molecular Neurobiology, 53, 968–982.