Acute toxicity, hepatotoxicity and renal-toxicity profile of the crude methanol extract of Mallotus oppositifolius (Geisel.) (Euphorbiaceae) combined with honey in albino rats
1 Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
2 Department of Nutrition and Dietetics, Faculty of Agricultural Sciences, University of Nigeria Nsuka, Nigeria.
3 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Federal University of Oye-Ekiti, Ekiti State, Nigeria.
4 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka.
5 Department of Botany, Faculty of Biosciences, Nnamdi Azikiwe University Awka.
6 Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, University of Nigeria Nsuka
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 23(01), 182–192.
Article DOI: 10.30574/gscbps.2023.23.1.0120
Publication history:
Received on 08 February 2023; revised on 12 April 2023; accepted on 15 April 2023
Abstract:
Background: Mallotus oppostifollous is a shrub used folklorically in traditional medicine for the treatment and management of different diseases including infections, wounds, and inflammation across tribes where they are found including South East Nigeria. This study was aimed to toxicity, renal-protective and hepato-protective effect of crude methanol extract of M. oppositifolius honey mixture in rats.
Methods: The powdered leaf extracts of M. oppositifolius was extracted by cold maceration using methanol. The acute toxicity, hepatotoxicity and renal-toxicity profile of the crude extract of M. oppositifolius were carried out using standard laboratory procedures.
Results: The result showed that Mallotus oppostifollous administered orally had LD50 above 5000mg/kg and showed no toxic effect on the blood, kidney and liver of the rats when used orally. It stabilized the blood hematology and biochemical parameters. It showed no significant elevation on the creatinine, blood urea nitrogen and uric acid and therefore showed that the honey combination could have a stabilizing effect on the vital organs of the rats.
Conclusion: We therefore conclude that the crude extract of Mallotus oppostifollous has no toxic effect against the kidney, liver and blood parameters and therefore is safe for consumption as a phytomedicine. Therefore, we recommend its continued usage for the treatment of diseases.
Keywords:
Mallotus oppostifollous; Acute toxicity; Subacute toxicity; Renal protective; Hepatoprotective; Biochemical; Hematological
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