Advanced phytochemistry and chemo-metric profiling of the bioactive medicinal components of n-hexane seed extract of Xylopia aethiopica using FTIR and GC-MS techniques
1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences. University of Port Harcourt, East/West Road, PMB 5323 Choba Rivers State, 500001 Nigeria.
2 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences. Madonna University Elele, Rivers State, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 22(01), 247-256.
Article DOI: 10.30574/gscbps.2023.22.1.0031
Publication history:
Received on 03 December 2022; revised on 20 January 2023; accepted on 22 January 2023
Abstract:
The use of herbal medicine has achieved global success as an ethno-medicine, yet there are lots of drawbacks in their commercial value and wide acceptance due to poor regulation and standardization. Present study aims to chemo-metrically characterize the phyto-chemical principles present in the n-hexane seed extracts of Xylopia aethiopica using chromatographic and spectroscopic methods. The crude n-hexane extracts were analyzed using Fourier Transform Infrared Spectroscopy (FTIR) model 8400S and GC-MS (Model-QP 2010 plus Spec). The identification of compounds was done using NIST ver.2.0-year 2005 Library. The biological activity are based on Dr. Duke’s phytochemical and ethno-botanical databases. The FTIR revealed functional groups such as alkenes, alkanes, alcohols, aromatic rings as well as fatty acids. The GC-MS revealed phyto-compounds such as alpha-Terpineol, alpha-cubabene, pinocarvone, copaene and alpha-muurolene. The presence of these vital phytochemicals with excellent pharmacological activity may explain their usage in traditional medicine.
Keywords:
Xylopia aethiopica; GC-MS.; FTIR; Phytochemical database; Spectroscopy; Herbal medicine
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
