Ameliorative efficacy of Sepia officinalis ink extract on hepatorenal injury-induced following high-dose folic acid supplementation in rats
1 Faculty of biotechnology, October University for Modern Sciences and Arts, Egypt.
2 Zoology Department - Faculty of Science - Cairo University, Egypt.
3 Department of zoology, Faculty of arts and sciences Alabyar, University of Benghazi, Libya.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 17(03), 038–046.
Article DOI: 10.30574/gscbps.2021.17.3.0347
Publication history:
Received on 30 October 2021; revised on 03 December 2021; accepted on 05 December 2021
Abstract:
Sepia ink, a black suspension of melanin granules, is a multifunctional marine bioactive material. The present study aims to evaluate the ameliorative effect of the ink extract (IE) of the cuttlefish (Sepia officinalis) during high dosage administration of the FA in rats. Kidney injury induced by a single oral dose of FA (250 mg /kg). Eighteen male Wistar albino rats were the control, FA group, and FA+ IE group (250mg/kg). The IE showed a significant ameliorative effect against hepatorenal injury induced by high intake of FA as evident by decreasing the levels of serum aminotransferases (AST and ALT), urea, creatinine, uric acid, and significantly increased total serum albumin. Treatment with IE normalized the antioxidant status of the injured animals by reducing the MDA and the significant increase in the levels of GSH and CAT. The present study revealed that IE had an insightful effect against hepatorenal injury-induced following high intake of FA in rats, as it alleviates the alterations in the oxidative stress markers.
Keywords:
Sepia officinalis; Folic acid; Antioxidant; Ink; Oxidative stress
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