Anti-plasmodial, analgesic and anti-inflammatory activities of crude and alkaloidal fraction of Terminalia glaucescens stem bark
Department of Biochemistry, Federal University of Technology, Minna, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 08(03), 060-069.
Article DOI: 10.30574/gscbps.2019.8.3.0169
Publication history:
Received on 01 July 2019; revised on 05 September 2019; accepted on 10 September 2019
Abstract:
Terminalia glaucescens (T. glaucescens) stem bark is used in ethno-medicine for the management of malaria and other diseases in Northern Nigeria. In this study, antiplasmodial, analgesic and anti-inflammatory activities of crude and alkaloidal extracts of T. glaucescens stem bark were evaluated against Plasmodium berghei in mice. Six (6) groups of 3 mice each were inoculated with Plasmodium berghei infected blood. Groups I to V were treated orally with 250 and 500 mg/kg bw crude methanol extract of T. glaucescens stem bark, 100 mg/kgbw of alkaloidal fraction, 100 mg/kg body weight Artemisia herbal and 5 mg/kg bw chloroquine, once daily for five days. Analgesic and anti-inflammatory activities of the crude extract were evaluated at doses of 400 and 800 mg/kg bw. Results shows that chloroquine reduced the parasitaemia level the most (89.20 %) this was followed by Artemisia herbal standard (72.80 %) and alkaloidal extract recorded 72.07 % parasitaemia reduction. The extract caused an increase in packed cell volume and body weight of the animal. The analgesic and anti-inflammatory effects of crude extract of T. glaucescens stem bark (800 mg/kg body weight) were 56.86 and 78.79 % respectively compared to the acetyl salicylic acid standard drug (75.68 and 95.96 %) respectively. From the study Terminalia glaucescens stem bark extract was found to possess antimalarial, analgesic and anti-inflammatory properties, which however was lower than that of the standards used. This however, provides a scientific basis to the folkloric claim of the plant in the management of pain and similar ailments.
Keywords:
Malaria; Analgesic; Anti-Inflammatory; Alkaloid; Terminalia glaucescens
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
