Antibiotic resistance in Escherichia coli from urine of patients with suspected urinary tract infections accessing Dalhatu Araf Specialist Hospital, Lafia, Nigeria
1 Department of Microbiology, Nasarawa State University, P.M.B 1022, Keffi, Nasarawa State, Nigeria.
2 World Health Organization, Nigeria Country Office, UN House, Plot 617/618, Diplomatic Drive, Central Business District, P.M.B. 2861, Garki, Abuja, Nigeria
3 Department of Science Laboratory Technology, Nasarawa State University, P.M.B. 1022, Keffi, Nasarawa State, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 08(02), 106-112.
Article DOI: 10.30574/gscbps.2019.8.2.0146
Publication history:
Received on 31 July 2019; revised on 16 August 2019; accepted on 20 August 2019
Abstract:
The wide use of antibiotics to treat urinary tract infection (UTIs) caused by bacteria is compromised by the development of resistance mechanisms in bacteria. This study evaluated the antibiotic resistance in Escherichia coli from urine of patients with suspected UTI in Dalhatu Araf Specialist Hospital, Lafia, Nigeria. Four hundred urine samples of suspected UTI patients were collected and E. coli was isolated and identified using standard microbiological methods. Antimicrobial Susceptibility Testing for the isolates was carried out and interpreted as described by the Clinical and Laboratory Standards Institute (CLSI). The occurrence of the bacterium was 14.5 % (58/400). The occurrence was higher in female (15.8 %) than the male (12.5 %); and highest at > 50 years (31.8 %). The isolates were more resistant to ampicillin (79.3 %), streptomycin (62.0 %) and cefoxitin (58.6 %) but less resistant to gentamicin (15.8 %), imipenem (18.9 %) and amoxicillin/clavulanic acid (27.6 %). The occurrence of multi-drug resistance (MDR) isolates was 87.9%. The antibiotics namely gentamicin, imipenem and amoxicillin/clavulanic acid were very effective against the isolates and most of the isolates were MDR. There is thus a need for the hospital to limit its antibiotic use in the light of these observations.
Keywords:
Escherichia coli; Urine; Antibiotics; Resistance
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
