Antidepressant in animal models of depression and study of cognitive property
1 Department of Quality Assurance, Agnihotri College of Pharmacy, Wardha, Pin 442001 Maharashtra India.
2 PDM School of Pharmacy, Karsindhu, Safidon, Jind 126112 Haryana, India.
3 Jamanlal Goyanka Dental College and Hospital, Akola 444002 Maharashtra India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 07(03), 064–076.
Article DOI: 10.30574/gscbps.2019.7.3.0069
Publication history:
Received on 15 April 2019; revised on 15 June 2019; accepted on 20 June 2019
Abstract:
Depression characterized by significant depression of mood and impairment of function. In whole study evaluate the antidepressant activity of ethanolic extract of Bacopa monnieri Linn, to assess the pharmacodynamic interaction of drug with standard nootropic antidepressant, determine effect of drug alone and in combination with standard anti-depressant in brain on amino acid neurotransmitter and acetylcholine esterase activity. Despair Swim test and tail suspension test study of interaction of ethanolic extract Bacopa monnieri with standard antidepressant drug extract used in FST and TST studied. Final perception was GABAmimetic Bacopa monneri decrease the immobility in forced swim test found that GABAergic activity lower in depressed state than normal brain. The control group in both FST and TST. GABA level found decrease than basal values. From experimental evidence it may conclude that ethanolic extract of Bacopa monnieri Linn possesses significant antidepressant activity.
Keywords:
Bacopa monnieri Linn; Forced swim test; Tail suspension test; GABAergic activity
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
