Antigastric ulcer activity of Ludwigia octovalvis (Jacq.) P. H. Raven (ONAGRACEAE) hydroalcoholic extract
1 Department of Pharmacology, Sciences Faculty, BP 906, University of Antananarivo, Madagascar.
2 Department of Chimistry, Sciences Faculty, BP 1246-301, University of Fianarantsoa, Madagascar.
3 School for International Training (SIT), Study Abroad Madagascar, Kipling Road, Brattleboro, Vermont 05302, USA.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 21(03), 077-081.
Article DOI: 10.30574/gscbps.2022.21.3.0463
Publication history:
Received on 30 October 2022; revised on 04 Decemeber 2022; accepted on 07 December 2022
Abstract:
Ludwigia octovalvis is used to treat stomachache in Malagasy traditional medicine. The present study was carried out to evaluate the anti-ulcer activity of its hydroalcoholic leaf extract in rats. Pylorus ligation and indomethacin-induced models were used to evaluate its anti-secretory and mucoprotective activities. Cimetidine (100 mg/kg) and Misoprostol (1.43 µg/kg) were used as the standard drugs. The extract was administered orally at doses 150, 300 and 600 mg/kg. The extract exhibited significant ulcer inhibition in indomethacin-induced ulcer model. The lesion surface area of the control group mucosa is equal to 6.2 ± 0.50 mm2, versus 4.32 ± 0.1, 2.75 ± 0.10 and 1.12 ± 0.05 mm2 in rat treated with the extract, and 2.1 ± 0.1 mm2 for the rats treated with misoprostol (p<0.05). It also reduces the gastric content acidity, which is equal to 2.79 ± 0.1 in control group, to 3.13 ± 0.1, 3.25 ± 0.2 and 5.31 ± 0.2 in the animals treated with the extract and 5.79± 0.1 for the animals treated with cimetidine (p<0.05). The extract showed significant reduction in mucosa lesion surface area and gastric content acidity, dose dependent compared to control.
Keywords:
Ludwigia octovalis; Anti-secretory; mucoprotective; Anti-ulcer; Rat
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