The antihypertensive effect of the ethanol seed extract of Persea americana Mill in albino Wistar rats
1 Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
2 Department of Pharmacology and Therapeutic, Faculty of Basic Clinical Sciences, Alex Ekwueme Federal University, Ndifu Alike Ikwo, Nigeria.
3 Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Ebonyi State University, Abakaliki, Nigeria.
4 Department of Haematology, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
5 Department of Pharmacology, Faculty of Pharmacy, Madonna University, Rivers State, Nigeria, Elele Campus, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 30(01), 038-045.
Article DOI: 10.30574/gscbps.2025.30.1.0494
Publication history:
Received on 19 November 2024; revised on 01 January 2025; accepted on 03 January 2025
Abstract:
Aim: Hypertension is a medical condition in which the arterial blood pressure is persistently elevated. This condition can lead to multiple complications, organ damage and death. The aim of this study was to assess the antihypertensive effects of ethanol seed extracts of Persea americana mill
Method: Wister rats used were divided into 14 groups of which 13 groups were induced with cadmium chloride for 2weeks and made hypertensive, a group not induced used as negative control. Thereafter Persea americana mill extract and fractions were administered to 8 groups of experimental rats at 200mg/kg bodyweight and 400mg/kg body weight via oral gavage. Four groups of the experimental animals were given standard Antihypertensive while a group was used as positive control
Results: Findings show that after 2weeks of the treatment with the ethanol seed extracts of Persea americana mill and it's fractions,the blood pressure of all animals were reduced significantly compared to standard antihypertensive drugs with the exception of animals treated with 400mg/kg methanol fractions whose blood pressure reduction was not significant compared to ones treated with standard antihypertensive drugs
Conclusion: Therefore, Avocado seeds (Persea americana mill) can be used as local or traditional antihypertensive.
Keywords:
Hypertension; Antihypertensive; Persea Americana; Blood pressure; Wistar rats
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