Antipyretic effect of ethanol extract of plant leaves of garden croton (Codiaeum variegatum) in male mice
1 Department of Biology, Faculty of Math and Sciences, University of Lampung, Bandar Lampung, Indonesia.
2 Department of Pharmacy, Faculty of Math and Sciences, Tulangbawang University, Bandar Lampung, Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 14(03), 202-206.
Article DOI: 10.30574/gscbps.2021.14.3.0087
Publication history:
Received on 17 February 2021; revised on 21 March 2021; accepted on 23 March 2021
Abstract:
Codiaeum variegatum (L.) is known to contain bioactive compounds that have many pharmacological properties such as abortifacient, antiamoebic, antibacterial, anticancer, antifungal, and antioxidant. This study aims to reveal whether the ethanol fraction of leaf extract of this plant has antipyretic activity. The male mice (n=25) with a weigh range of 20 – 30 g were divided into five groups (5 mice each). To make pyrexia condition, the animals were induced with DPT-HB-HIB vaccine. The ingredients given to the animals were as follows: distilled water as the negative control; standard drug (paracetamol) as positive control; and three different dosage of croton leaves extract namely: 71.5, 143 and 286 mg/kg BW. The body temperature of the mice was measured using a digital thermometer through the rectal opening every 30 minutes for 180 minutes. The results showed that ethanol fraction of croton plant leaf extract at the dosage of 143 and 286 mg/kg BW statistically have the same effect as paracetamol in decreasing body temperature of mice. Therefore, it can be concluded that plant extract of garden croton is potential to be used as antipyretic remedy.
Keywords:
Codiaeum variegatum; Garden croton; Antipyretic drug; Puring
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Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
