Antiulcerogenic activities of Agelanthus dodoneifolius leaf against acetyl salicylate and ethanol induced ulceration in rats
Department of Biochemistry, Federal University of Technology, Minna. Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 09(01), 053-061.
Article DOI: 10.30574/gscbps.2019.9.1.0181
Publication history:
Received on 21 August 2019; revised on 28 September 2019; accepted on 30 September 2019
Abstract:
Antiulcer and antioxidant activities of crude methanol (800 and 1600 mg/kg bw), n-hexane and ethyl acetate fractions (800 mg/kg bw) of Agelanthus dodoneifolius were investigated against acetylsalicylate and ethanol induced ulcer in rats. The methanol fraction had the highest ulcer protective effect (73.33 ± 7.40%), better than the cimetidine (60.00±8.54 %) while the ethyl acetate fraction had the least (26.66 ± 6.66 %) in ethanol model, however, in acetyl salicylate model, crude extract exhibited the highest (54.16 ± 4.16 %) and the lowest (33.33 ± 4.16 %) protective effect at 1600 and 800 mg/kgbw respectively. The methanol faction preserved the integrity of the epithelial mucosal better than the other fractions. Treatment with crude and fractions of A. dodenofolius significantly (p<0.05) increased the activities of SOD and Catalase and decreases the MDA concentration when compared with ulcerative untreated rats in both ulcer models. In conclusion, A. dodoneifolius could serve as a sources of new plant based antiulcer agent.
Keywords:
Methanol extract; Agelanthus dodoneifolius; Acetyl salisylate induced; Ethanol induced; Ulcer protective activity
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
