Assessment of efficacy of ticagrelor versus clopidogrel in the treatment of myocardial infarction by 2D echocardiography
1Bharat Institute of technology, Department of Pharmacognosy, Mangalpally, Ibrahimpatnam, Hyderabad, India – 501510.
2 Pharm D-V year, Department of Pharm D, Bharat School of pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, India- 501510.
3 Assistant professor, Department of Pharm D, Bharat School of pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, India- 501510.
4 Interventional cardiologist, Department of Cardiology, Durgabhai Deshmukh Hospital and Research Centre, Vidya Nagar, Hyderabad, India.
Case Study
GSC Biological and Pharmaceutical Sciences, 2020, 12(03), 013-016.
Article DOI: 10.30574/gscbps.2020.12.3.0256
Publication history:
Received on 07 August 2020; revised on 31 August 2020; accepted on 03 September 2020
Abstract:
Myocardial infarction (MI) is the irreversible death of heart muscle due to prolonged lack of supply of oxygen resulting in decreased coronary blood flow and if untreated may lead to myocardial damage. Myocardial infarction may be due to several causes viz., coronary occlusion, ventricular hypertrophy, coronary artery emboli or coronary trauma. Drugs used for the treatment of MI includes vasodilators to dilate the arteries and veins, antiarrythmics, thrombolytics to dissolve clots, anti-thrombolytics to prevent thrombus formation, anti-platelet drugs, analgesics to reduce pain, cardiac depressants to control heart rate and contractions. Present study was undertaken to evaluate the efficacy of Ticagrelor v/s Clopidogrel the antiplatelet drugs indicated in patients to reduce the risk of myocardial infarction. Both the drugs act by preventing the formation of platelet clots and helps in the smooth flow of blood. Assessment of results was carried out by 2d Echo test to evaluate the efficacy of the treatment. Treatment with ticagrelor showed improved efficacy and safety by improving the ejection fraction, reducing the rate of stroke, reducing vascular abnormalities, showing no bleeding problems. No death is observed due to vascular problems in both the treatment. Ticagrelor revealed considerable recovery rate compared to clopidogrel. Study reports revealed that ticagrelorisefficient thanclopidogrel in the treatment of MI and is a better choice over clopidogrel to treat MI.
Keywords:
Myocardial infarction; Anti-platelet; Ticagrelor; clopidogrel; 2D echo
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