Blood glucose lowering effect of Solanum melongena (garden egg), Solanum lycopersicum (tomatoes), Daucus carota subsp. Sativus (carrot) extracts on lead induced toxicity in albino wistar rats
Biochemistry Department, Faculty of Natural and Applied Sciences,Veritas University, Abuja, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 14(01), 065-070.
Article DOI: 10.30574/gscbps.2021.14.1.0007
Publication history:
Received on 03 January 2021; revised on 10 January 2021; accepted on 11 January 2021
Abstract:
Lead is one of the heavy metal humans are often expose to either through food, cosmetics or environment. This study is aimed at investigating the positive effect of Solanum melongena (garden egg), Solanum lycopersicum (tomatoes) and Daucus carrots subsp.sativus (carrot) on blood glucose concentration, body weight, and feeding habits of albino rats on lead toxicity. In this study 35 albino rats weighing 80-120g were grouped into five. Group 1 served as normal control, group 2 negative control. The remaining three groups served as treatment groups 1, 2 and 3. All groups except group 1 (normal control) were administered 50mg/kg of lead acetate. Treatment groups were administered 200mg/kg of Solanum melongena (garden egg), Solanum lycopersicum (tomatoes) and Daucus carrots subsp.sativus (carrot). Group 3 was administered Solanum malongen and Daucus carrots subsp.sativus while group 4 was given Daucus carrots subsp.sativus and solanum lycopersicon. Group 5 was administered Solanum malongen, Daucus carrots subsp.sativus and Solanum lycopersicon. Changes in blood glucose concentration, body weight, feed and water consumption recorded at intervals. The result showed a significant decrease (P<0.05 and P<0.01) in blood glucose concentration in treatment groups compared to negative control. There was also significant increase (P>0.05, P>0.01 and P>0.001) in body weight and feed consumed in treatment groups compared to negative control. Combined therapy of any two of Solanum malongen, Daucus carrots subsp.sativus and Solanum lycopersicon juice can help in the management of hyperglycemia and reverse internal abnormality or injury resulting in weight loss in lead induced toxicity.
Keywords:
Lead toxicity; Hyperglycemia; Body weight; Glucose concentration fresh juice
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