Characterization of nano encapsulated cinnamon bark extract (Cinnamomum burmannii) based on chitosan alginate as a potential drug delivery system for cervical cancer therapy
1 Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga Indonesia.
2 National Research and Innovation Agency, Research Organization for Life Sciences and Environment, Bogor, Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 30(02), 135-141.
Article DOI: 10.30574/gscbps.2025.30.2.0047
Publication history:
Received on 25 December 2024; revised on 10 February 2025; accepted on 13 February 2025
Abstract:
Objective: This study aims to evaluate the nanoencapsulation potential of cinnamon extract based on the results of characterization tests.
Method: Formulation F2 using a combination of 1% chitosan and 1.5% alginate showed optimal characterization results compared to F1 and F3.
Results: The results showed that formulation F2 had a particle size of 246.3 nm, PDI of 0.396, and zeta potential of -33.8 mV indicating good physical stability, homogeneous particle distribution, and suitable particle size for nanoencapsulation applications. In addition, particle visualization showed clear and uniform physical properties, while a pH test of 7.32 supported suitability for oral delivery.
Conclusion: Based on these characterization results, nanoencapsulation of cinnamon bark extract using chitosan alginate polymer shows significant potential as a drug delivery system for cervical cancer therapy
Keywords:
Alginate; Cervical Cancer; Chitosan; Cinnamomum burmannii; Nanoencapsulation
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
