A critical review on the experimental model of animal for antigout drugs
Department of Pharmacology, Dr. Rajendra Gode College of Pharmacy, Malkapur, Maharashtra, India 443101.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(02), 282–287.
Article DOI: 10.30574/gscbps.2022.19.2.0201
Publication history:
Received on 20 April 2022; revised on 23 May 2022; accepted on 26 May 2022
Abstract:
In this era where the pharmaceutical companies and products are hiking in its need and production it is inevitable to document the safety and toxicity along with the indications of the same. This is where the experimental study has a vital role to play. Experimental pharmacology is the science where the drug interaction with different receptors and target sites in living organism are explained. This article reviews about the different aspects of experimental pharmacology and its uses. Gout is an acute inflammatory disease characterized by the presence of uric acid crystals in the joint. This event promotes neutrophil infiltration and activation that leads to tissue damage. Mice received oral administration of BL or saline daily for 7 days and then were injected with MSU in the knee cavity. The present review aims to provide an updated overview on history, types, uses and mechanism of drug treatment for gout (hyperuricemia) with the detail review on information about experimental model of antigout drugs, their operating procedure, these agent works correct overproduction or under excretion of uric acid.
Keywords:
Gout; Inflammatory disease; Experimental pharmacology
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
