Dengue fever: Causes, complications, and vaccine strategies – A review
Department of Microbiology, Annamalai University, Chidambaram, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2019, 06(03), 016–023.
Article DOI: 10.30574/gscbps.2019.6.3.0024
Publication history:
Received on 13 February 2019; revised on 28 February 2019; accepted on 04 March 2019
Abstract:
Dengue is an extremely endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the four serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution. Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes. Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age. The impact of its limited application to the public health system needs to be evaluated. Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and native individuals. In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and native individuals.
Keywords:
Dengue; Dengue causes; Complications; Vaccine
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
