Develop and evaluate novel drug delivery system of valsartan for treatment of Hypertension: A review
1 Department of Pharmaceutics, Kisan Vidya Prasarak Sansthas, Institute of Pharmaceutical Education, Boradi, Shirpur, Dist.- Dhule 425428, Maharashtra, India.
2 Department of Pharmacology, Kisan Vidya Prasarak Sansthas, Institute of Pharmaceutical Education, Boradi, Shirpur, Dist.- Dhule 425428, Maharashtra, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2021, 15(03), 302–306.
Article DOI: 10.30574/gscbps.2021.15.3.0179
Publication history:
Received on 20 May 2021; revised on 22 June 2021; accepted on 24 June 2021
Abstract:
The sustained release tablets were formulated by using the combination of various release retardant polymers/excipient. The polymers used were hydroxypropyl methylcellulose, Micro Crystalline Cellulose and Sodium starch glycolate. The present investigation involves formulation and evaluation of sustained release tablets of Valsartan with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. It showed good linearity and reproducibility which also indicated the analytical method used in the present study to be suitable for the estimation of the drug candidates in different dissolution media. Evaluation parameters such as thickness and diameter, weight variation and drug content uniformity test. The observation for all above evaluation parameters indicate that the values are within the IP specified limits. Thus, on the basis of our research findings it could be concluded that the performance of the developed sustained release tablets was found to be promising for the treatment of hypertension.
Keywords:
Sustained; Hypertension; Cellulose; Linearity; Polymers; Valsartan
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