Development and evaluation of sustained release microparticles of atenolol of gastrointestinal delivery
Dhanvanthari Institute of Pharmaceutical Sciences, Kothagudem, Telangana, India, 507120.
Research Article
GSC Biological and Pharmaceutical Sciences, 2018, 03(02), 001–005.
Article DOI: 10.30574/gscbps.2018.3.2.0026
Publication history:
Received on 25 March 2018; revised on 14 May 2018; accepted on 15 May 2018
Abstract:
The aim of the present study is to development and evaluation of sustained release micro particulates of atenolol prepared by solvent evaporation technique. In this method Eudragit RS-100 was dissolved in Acetone and suitable solvent was mixed well with the pure Atenolol drug with different ratios and filtered it. Add magnesium stearate and it was dispersed in solution by ultra sonification. This solution keep it on a side and take another fresh beaker contain 100 ml of liquid paraffin and add 20 ml of n-hexane. Both liquid paraffin and n-hexane stirred continuously by using mechanical stirrer. In this solution add previous ultra sonification solution in the form of drops with the help of syringe until acetone evaporated. By this process microparticles were formed and they dried at room temperature. The drug product percentage yield, drug entrapment efficiency, particles size parameters are in desired manner. The in-vitro drug release studies Shows that the percentage of drug release is in standard level. Among all formulations F3 and F5 formulations with drug, polymer was found to be satisfactory in terms of excellent micromeritic properties, percent yield (92.12%), Drug entrapment efficiency (77.79%), Percent buoyancy (80%) and highest in-vitro drug release of 85.60% in sustained manner over an extended period of time for 12 hrs.
Keywords:
Atenolol; Microparticles; Eudragit RL 100; Magnesium stearate
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Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.
