DNA Methylation: Bridging life’s experience and genetics within forensic scenario
Department of Forensic Science, Vivekananda Global University, Jaipur, Rajasthan, India- 303012.
Review Article
GSC Biological and Pharmaceutical Sciences, 2023, 23(02), 042–049.
Article DOI: 10.30574/gscbps.2023.23.2.0181
Publication history:
Received on 25 March 2023; revised on 01 May 2023; accepted on 04 May 2023
Abstract:
DNA serving as the “blueprints of life” is a complex found in all biological cells carrying the genetic instructions for development and functioning of the organism. Inheritance of unique combination of genetic polymorphism results in DNA profile. In past few decades, the field of forensic genetics has witnessed several advancements from the radio-labelled DNA probes to the Short Tandem Repeats (STR) and Single Nucleotide Polymorphism (SNP) that have fostered the emergence of biological materials as most reliable evidences at a crime scene for the purpose of human identification but then, are inadequate in distinguishing monozygotic twins. Also, these techniques are of unavailing in providing informations such as tissue-specificity of the DNA source, phenotypic identification, and age estimation. Epigenetics, particularly DNA methylation is evolving as a promising technique to overcome such drawbacks of conventional profiling techniques.
Keywords:
Monozygotic Twins; Tissue Source Identification; Ageing; Environmental Factor; DNA Methylation; Epigenetics
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
