Downstream processing of amorphous solid dispersions into tablets
1 Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Telangana, 506001 India.
2 Analytical Research & Development. Hikma Pharmaceuticals, Columbus, Ohio 43228, USA.
Review Article
GSC Biological and Pharmaceutical Sciences, 2023, 22(01), 170-177.
Article DOI: 10.30574/gscbps.2023.22.1.0013
Publication history:
Received on 01 December 2022; revised on 12 January 2023; accepted on 15 January 2023
Abstract:
Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with poor drug-polymer miscibility is a major challenge in the downstream processing of ASDs. While many downstream techniques are available for converting ASDs into final dosage forms, oral solids remain the most commercially viable. The type of excipients used in the conversion of ASDs into tablets are very similar to the excipients used in conventional tablets. For example, the binders used in conventional tablets are widely used as polymeric carriers in case of ASDs. The physical properties of ASDs manufactured using spray drying or hot melt extrusion pose major challenge in converting ASDs into oral tablets. The current review focuses on various challenges associated with converting ASDs into tablets and provide a comprehensive review on various excipients used in manufacturing tablets using ASDs.
Keywords:
Amorphous Solid Dispersions; Hot Melt Extrusion; Spray Drying; Tablets
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
