Dyslipidemia facilitates the progression of kidney function impairment in frequent administration of artemether-lumefantrine: An in vivo study
1 Department of Biochemistry, Faculty of Science, University of Uyo, Uyo, Nigeria.
2 Department of Epidemiology, Monitoring and Evaluation, Achieving Health Nigeria Initiative (AHNi), Nigeria.
3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(02), 138–145.
Article DOI: 10.30574/gscbps.2024.28.2.0298
Publication history:
Received on 29 June 2024; revised on 10 August 2024; accepted on 13 August 2024
Abstract:
The study investigated the effect of frequent administration of artemether-lumefantrine on biochemical parameters of kidney functions and the role of dyslipidemia in the progression of kidney disease. Male Wistar rats, weighing between 230 and 330 grams, were divided into five subgroups (n=7) of Group (I), control and received no medication, (2) 8 mg/kg bodyweight (bw) of artemether-lumefantrine for three days, (3) 12 mg/kg bw for three days, (4) 8 mg/kg bw three days a week for three weeks with a two-week recovery interval, (5)12 mg/kg bw three days a week for three weeks with a two-week recovery interval. Biochemical parameters investigated include serum lipid profile and kidney function biomarkers. A significant (p<0.05) decrease in high density lipoprotein cholesterol concentration across treatment groups compared to the control was observed. Triglyceride levels significantly (p<0.05) increased in Group 5, while total cholesterol levels significantly (p<0.05) decreased in Group V. No significant (p>0.05) changes were observed in low density lipoprotein-cholesterol and VLDL-cholesterol levels. Kidney function tests revealed a significant (p<0.05) increase in urea and creatinine concentrations in the treatment groups compared to the control. Serum electrolytes showed increases and decreases that were not significant. These findings highlight the nephrotoxic effect of repeated exposure to artemether-lumefantrine, suggesting caution in its indiscriminate use.
Keywords:
Artemether-lumefantrine; Kidney Functions; Lipid Profile; Malaria
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