The effect of ethanolic extract of Annona muricata leaf on the basal ganglia
1 Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria.
2 Department of Anatomy, Faculty of Basic Medical Sciences, Abia State University, Uturu, Abia State, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 06(03), 040–044.
Article DOI: 10.30574/gscbps.2019.6.3.0025
Publication history:
Received on 17 February 2019; revised on 05 March 2019; accepted on 08 March 2019
Abstract:
Annona muricata (Linn.) is an evergreen tropical tree of the Annonaceae family that possesses phytotherapeutic bioactive compounds known as annonaceous acetogenins effective for the treatment of cancers and several diseases. This study investigated the effect of ethanolic extract of Annona muricata leaf on the basal ganglia. Twenty four (24) adult wistar rats were randomly divided into four groups (A, B, C & D) of six animals each. Group A served as the control and received 2 ml/kg of distilled water; the experimental groups B, C & D were orally administered 100 mg/kg, 200 mg/kg and 300 mg/kg body weight of ethanolic extract of Annona muricata leaf respectively for thirty days. At the end of administration, the animals were anaesthetized under the influence of chloroform vapour, dissected and their brain harvested for histological examination. The histological result revealed mild increase in the number of basal ganglia nuclei cell body (BGNCB) and fibres (F) with mild necrosis of neurons when compared to their control group. In conclusion, high consumption of ethanolic extract of Annona muricata could result in extrapyramidal side effects. Thus, it should be taken at lower doses.
Keywords:
Annona muricata; Basal ganglia; Wistar rats; Histology
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
