Effect of Taraxacum officinale L. ethanol extract against kidney injuries induced by paracetamol in rats
1 Horasan Vocational School, Ataturk University, Erzurum, Turkey.
2 Faculty of Veterinary, Department of Biochemistry, Ataturk University, Erzurum, Turkey.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 21(01), 144–151.
Article DOI: 10.30574/gscbps.2022.21.1.0385
Publication history:
Received on 04 September 2022; revised on 12 October 2022; accepted on 15 October 2022
Abstract:
Background/Aim: The biochemical effects of dandelion (D) ethanol extract on blood and renal tissue in rats induced by paracetamol (PRC) were examined in this study.
Methods: In this study was utilized 36 Sprague Dawley male rats, aged 5 months. Rats were divided 6 groups of 6 rats each, randomly. Control group (C), D200 group, D250 group, PRC group, PRC+D200 group, PRC+D250 group, was given orally per os (p.o) in a single dosage (2 g/kg/b.w.) and dandelion extract (200-250 mg/kg) was given intraperitoneally (i.p) for 8 days.
Results PRC raised plasma levels of urea, uric acid, and creatinine, as well as malondialdehyde, nitrate, and nitrite in kidney tissue. Furthermore, antioxidant levels/activities in renal tissue were reduced. Dandelion reduced plasma levels of urea, uric acid, and creatinine, as well as lipid peroxidation, nitrat, and nitrit in kidney tissue, while simultaneously increasing antioxidant activities.
Conclusion: In this study was investigated that dandelion ethanol extract can be used excellent protection against PRC damage.
Keywords:
Antioxidant; Dandelion; Kidney; Oxidative stress; Paracetamol
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