Effect of a three-herb formulation on chronic inflammation induced by Freund's Complete Adjuvant in Wistar rats
1 Laboratory of Biology and Health, Pedagogical Research Unit: Pharmacodynamics Biochemical Laboratory Félix HOUPHOUËT-BOIGNY Cocody,UFR Biosciences, 22 BP 582 Abidjan 22, Côte d'Ivoire.
2 Immunity Biology Unit, Pasteur Institute, 01 PO BOX 490 Abidjan 01, Côte d'Ivoire.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 30(02), 242-251.
Article DOI: 10.30574/gscbps.2025.30.2.0055
Publication history:
Received on 31 December 2024; revised on 10 February 2025; accepted on 13 February 2025
Abstract:
New innovative therapies are urgently needed to combat the high morbidity associated with sickle cell crises. Given the many side effects associated with conventional anti-inflammatories, the use of herbal medicines would be beneficial for patients. In an effort to help manage chronic inflammation in sickle cell disease, a three-herb recipe was used to test the anti-inflammatory activity elicited by Freund's Complete Adjuvent in Wistar rats. Rats' pulp volume and hematological parameters were measured. After the 20 days of treatment, the extracts from the recipe reduced the edema caused by CFA and the proliferation of the number of leukocytes, the level of fibrinogen and also increased the level of hemoglobin which is the key parameter of anemia. These observed effects are due to the antioxidant power of phenolic compounds and alkaloids, the terpenoids present in the extracts of ZHm.
Keywords:
Herb Formulation; Chronic Inflammation; Freund's Complete Adjuvent; Wistar Rats
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
