Effects of hydroethanolic formulations based on Garcinia kola kernel and Chrysophlum cainito leaves on the organs of diabetic mice
1 Food Biochemistry and Tropical Products Technology Laboratory, Department of food Science and Technology,NANGUI ABROGOUA University, Abidjan, BP 801, Abidjan 02, Côte d'Ivoire.
2 Laboratory of Biotechnology and food Microbiology, Department of Food Sciences and Technology, Nangui Abrogoua University, Abidjan, Côte d’Ivoire, BP 801, Abidjan 02, Côte d'Ivoire.
3 Swiss Centre for Scientific Research in Cote d’Ivoire, 01 BP 1303 Abidjan 03, Côte d'Ivoire.
4 L Botany and Plant Diversity Development Laboratory, NANGUI ABROGOUA University, Abidjan, Côte D’Ivoire, BP 801, Abidjan 02, Côte d'Ivoire.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(02), 162–167.
Article DOI: 10.30574/gscbps.2024.28.2.0303
Publication history:
Received on 05 July 2024; revised on 13 August 2024; accepted on 16 August 2024
Abstract:
Plant extracts and their concentrates are natural bioactive compounds that are widely and effectively used as antibiotic alternatives in traditional medicine. This study was conducted to investigate the effects of formulated extracts of Garcinia kola kernel and Crhysophylum cainito leaves on the organs of mice. To this end, an experimental study was conducted over three weeks in the laboratory on eight batches of mice, 7 of which were made diabetic by intraperitoneal injection of 150 mg/kg of alloxane. The hydroethanol formulation of the extract was administered daily by gavage to 5 batches of diabetic rats at a concentration of 4000 mg/kg body weight. The non-diabetic batch and one diabetic batch received physiological water and were used as untreated normoglycaemic and diabetic controls. The remaining diabetic batch was treated with a reference drug, glibenclamide. The results showed that in the lungs, formulation extracts F2 and F4 significantly reduced lung weight, with respective values of (0.05 g) and (0.10 g) compared with the reference weight of 0.18 g of the normoglycaemic control (TNG). However, extracts of formulations F3 and F5 had no effect on lung weight in the treated groups. As for the heart, the results showed that during the 3 weeks of treatment, formulations F2, F3, F4 and F5 had no negative effect on heart weight. From the results obtained, we can conclude that the hydro-ethanol formulation extracts of Garcinia kola kernel and Chrysophylum cainito leaves have hepatoprotective properties.
Keywords:
Diabetes; Garcinia kola; Chrysophylum caimito; Hydroethanol extract; Mice
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