Epigenetics in reproductive infertility: A review
1 Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Durango, México.
2 Genetics Department, Faculty of Medicine and Nutrition, Universidad Juárez del Estado de Durango. Durango, Durango, México.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 27(03), 149–153.
Article DOI: 10.30574/gscbps.2024.27.3.0233
Publication history:
Received on 05 May 2024; revised on 15 June 2024; accepted on 18 June 2024
Abstract:
Infertility poses a significant challenge to reproductive health worldwide and affects millions of individuals and couples. While genetic factors have traditionally been explored in the etiology of infertility, emerging evidence suggests that epigenetic modifications play a crucial role in reproductive health and infertility. This review delves into the intricate interplay between epigenetics and reproductive infertility, elucidating how epigenetic alterations in germ cells and gametes can impact fertility outcomes. We explore the dynamic nature of epigenetic mechanisms such as DNA methylation and histone modifications, shedding light on their involvement in regulating gene expression essential for proper reproductive function. Understanding the epigenetic basis of reproductive infertility holds promise for developing new diagnostic tools, personalized treatments, and preventive strategies.
Keywords:
Epigenetics; Infertility; Fertility; Germ cell
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
