Evaluating the efficacy of topical Centella asiatica in accelerating burn healing in animal models: A systematic review
1 Department of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
2 Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
3 Department of Dermato Venerology, Saiful Anwar General Hospital, Malang, Indonesia.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 29(02), 189–201.
Article DOI: 10.30574/gscbps.2024.29.2.0415
Publication history:
Received on 29 September 2024; revised on 11 November 2024; accepted on 14 November 2024
Abstract:
Centella asiatica (CA), a medicinal plant with historical use in traditional medicine, is rich in bioactive compounds like asiaticoside, madecassoside, and asiatic acid, which are known for their anti-inflammatory, antioxidant, and collagen-boosting properties. These compounds are especially beneficial in addressing the complexities of burn healing, which involves a balance between inflammation, tissue regeneration, and scarring. The review covers experimental studies focusing in CA in burn animal model from 2014 to 2024, focusing on various outcomes in the aspects of gross, histology, and markers. Results indicate that CA significantly accelerates healing by enhancing tissue repair processes and improving wound quality while reducing scar formation. However, variations in experimental methods, including differences in burn induction, CA formulation, and outcome measurements, highlight a need for standardized research protocols. Findings suggest that CA holds promise as a low-cost, effective therapeutic option for burn treatment, particularly valuable in low-resource settings. This review underlines the importance of further clinical trials to confirm CA’s therapeutic potential, with the goal of developing accessible and effective treatments for burn injuries in humans.
Keywords:
Centella asiatica; Burn healing; Wound healing; Animal models; Topical application
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
