Evaluation of anti-arthritic activity of Hyptis suaveolens seeds in rats
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research (VIPER), Naraspur – 502313.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 27(03), 077–098.
Article DOI: 10.30574/gscbps.2024.27.3.0225
Publication history:
Received on 27 April 2024; revised on 07 June 2024; accepted on 10 June 2024
Abstract:
Rheumatoid arthritis has been treated with Hyptis suaveolens (L) poit. seeds. There has been no pharmaceutical assessment for rheumatoid arthritis. A study aims to assess the anti-arthritic properties of aqueous extract of Hyptis suaveolens (L) poit… seeds (AEHS). Standard techniques were used for phytochemical analysis. Tested anti-arthritic potential in-vitro (25-800µg/ml egg albumin) and in vivo (200 and 400 mg/kg egg albumin induced arthritic model). Chemicals such alkaloids, sugars, flavonoids, phenols, and terpenoids were found. Results showed 75% reduction of protein denaturation at 800µg/ml in-vitro. According to the Egg albumin model, AEHS considerably (P < 0.0001) inhibits changes in paw volume, joint diameter, and body weight. It also improves hematological, biochemical, and histopathological levels. The findings confirm the traditional usage of Hyptis suaveolens(L)poit. seeds to treat rheumatoid arthritis.
Keywords:
Hyptis suaveolens; Rheumatoid arthritis; Protein denaturation; Egg albumin
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