Evaluation of antiulcer activity of herbal drugs on experimental animal: Myrica nagi (Myricaceae)
Department of Pharmacology, Vidyabharti college of Pharmacy, Amravati, Maharashtra, India 425405.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 20(02), 138–144.
Article DOI: 10.30574/gscbps.2022.20.2.0326
Publication history:
Received on 15 July 2022; revised on 16 August 2022; accepted on 18 August 2022
Abstract:
The anti-ulcer activity of Methanolic extract of Myrica nagi (Myricaceae) fruit MEMN was investigated in pylorus ligation and methanol-induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index MEMN at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions induced by Aspirin-induced ulcers & pylorus ligation-induced ulcers. The extract (200, 400 mg/kg) showed a significant (P < 0.001) reduction in gastric volume, free acidity and ulcer index as compared to the control. This present study indicates that Myrica nagi fruit extract has potential antiulcer activity in both models. These results may further suggest that methanolic extract was found to possess antiulcer genic as well as ulcer healing properties.
Keywords:
Herbal drug; Wistar rat; Antiulcer activity; Myrica nagi
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