Evaluation of the toxic effects of Albizia mahalao Capuron extracts, a Fabaceae from Madagascar, on different organisms
Laboratory of Applied Biochemistry in Medical Sciences, Department of Fundamental and Applied Biochemistry, Faculty of Sciences, University of Antananarivo, BP 906, Antananarivo 101, Madagascar.
Research Article
GSC Biological and Pharmaceutical Sciences, 2020, 11(02), 287-296.
Article DOI: 10.30574/gscbps.2020.11.2.0144
Publication history:
Received on 19 May 2020; revised on 24 May 2020; accepted on 27 May 2020
Abstract:
This work was designed to study the toxic effects of Albizia mahalao extracts on various organisms and explore their possible uses to fight against noxious organisms. Methanolic extracts of leaves (LME), stem (SME) and root (RME) barks, alkaloids (Alk) and saponosides (Sap) from leaves were tested. All extracts were toxic to mice with LD50 values by intraperitoneal route ranging from 69.18 (RME) to 135.52 mg/kg body weight (Alk). By oral route, at doses 5 and 10 times higher than intraperitoneal LD100 those extracts were not toxic. LME, SME and RME were toxic to carp alvins, frog tadpoles but not to chicks and mosquito Culex quinquefasciatus larvae. LC50 on carp alvins varied from 63.78 (RME) to 86.89 µg/mL (SME) and LC50 on frog tadpoles from 68.43 (RME) to 153.4 µg/mL (SME). All the methanolic extracts inhibited the germination of 53.8 % of the seed plants tested with inhibition percentages ranging from 20 to 100 %. In previous study, the same Albizia mahalao extracts were found to be efficient against many pathogenic bacteria at low doses. The extracts non-toxicity by oral route allowed envisaging their use to treat some diseases associated with these bacteria.
Keywords:
Albizia mahalao; Fabaceae; Toxicity; Alkaloids; Saponosides; Warm and Cold-blooded Animals; Seed Germination.
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
