Formulation and Development of Transdermal Patches
Department of Pharmaceutical Sciences, Kakatiya University, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(01), 346–352.
Article DOI:10.30574/gscbps.2022.19.1.0110
Publication history:
Received on 18 February 2022; revised on 04 April 2022; accepted on 07 April 2022
Abstract:
Transdermal patches have emerged as a cutting-edge technology in drug delivery systems, providing a non-invasive, controlled, and patient-friendly method for administering medications. These patches deliver drugs through the skin and into the bloodstream, bypassing the gastrointestinal tract and first-pass metabolism, thereby improving bioavailability and reducing systemic side effects. This review offers an in-depth examination of the formulation and development of transdermal patches, focusing on the critical components and materials used in their construction, including active pharmaceutical ingredients, polymer matrices, permeation enhancers, adhesives, backing layers, and release liners. The development process of transdermal patches is meticulously outlined, covering stages from preformulation studies and formulation development to prototype creation, in vivo studies, clinical trials, regulatory approval, scale-up, and market launch. Each step is essential for ensuring the safety, efficacy, and quality of the final product. Furthermore, this review addresses the common challenges encountered in the formulation and development of transdermal patches, such as overcoming the skin's barrier properties, selecting appropriate drug candidates, ensuring proper adhesion, maintaining stability, and managing patient variability. Strategies to overcome these challenges, including the use of chemical and physical permeation enhancers, innovative adhesive technologies, and rigorous clinical testing, are discussed in detail. By providing a comprehensive overview of the formulation and development of transdermal patches, this review aims to enhance understanding of the complexities involved in creating these advanced drug delivery systems.
Keywords:
Transdermal Patches; Drug Delivery; Formulation; Development Process; Challenges; Permeation Enhancers; Polymer Matrices; Adhesives
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Copyright information:
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
