Formulation and evaluation of bilastine loaded solid Self-Nano Emulsifying Drug Delivery System (s-SNEDDS) for oral administration: In-vitro characterization
Centre for Pharmaceutical Sciences, University College of Engineering, Science & Technology, JNTU Hyderabad, Telangana, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 25(03), 167–178.
Article DOI: 10.30574/gscbps.2023.25.3.0529
Publication history:
Received on 08 November 2023; revised on 23 December 2023; accepted on 25 December 2023
Abstract:
The aim of this study was to prepare an oral administrable SNEDDS for poorly water soluble drugs Bilastine. To choose the SNEDDS excipients, a ternary phase diagram and solubility assessment were conducted. A components of oil (capmul PG-NF) surfactant (Tween 40) and co-surfactant (Capryol 90) were used as the excipients. The optimized formulation was characterized for In-vitro analysis. The prepared S-SNEDDs exhibited good flow characteristics and Particle size (148.5dnm), zeta potential (−28.6), PDI (0.242), drug loading efficiency, % CDR of the optimized S-SNEDDs [TP3PG1 (2:8)] was found to be 103.61 ±0.678, 98.65% respectively. The formulation was stable over a 3-month storage period at 25 ◦C and 4 ◦C in terms of particle size, physical appearance, and drug loading. Overall, a range of lipid based SNEDDS liquid, solid formulations were successfully developed and seem to be a promising alternative to improving the solubility of poorly water-soluble drugs and evaluating In-vitro characterizations.
Keywords:
Self-nanoemulsifying drug delivery system (SNEDDS); Capmul PG-NF; Tween 40; Capryol 90; Bilastine; solubility enhancement; In-vitro drug release.
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
