Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine
Department of Pharmaceutics, Pioneer Pharmacy Degree College, Vadodara 390019, Gujarat, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 22(01), 345–350.
Article DOI: 10.30574/gscbps.2023.22.1.0039
Publication history:
Received on 09 December 2022; revised on 21 January 2023; accepted on 24 January 2023
Abstract:
Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine.
Method: To enhance the solubility of cilnidipine solvent evaporation method was used. In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and poloxamer 188(for ternary solid dispersion) were used in the different drug polymer ratio.
Conclusion: Among them cilnidipine: HPMC: poloxamer 188 shows better solubility and also different physical characterization test like DSC and XRD. After selection of best ternary solid dispersion fast dissolving tablets of cilnidipine were prepared using direct compration method via using different super disintegrant.
Keywords:
Cilnidipine; Solid dispersion; Fast dissolving tablet; Poloxamer; Ternary complex
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
