Glycated haemoglobin measurement at the biochemistry laboratory of the university Hospital - Joseph Ravoahangy Andrianavalona

Miora Koloina RANAIVOSOA 1, Jocia Fenomanana 2, *, Zoely Haingotiana RANAIVOSOA 1 and Andry RASAMINDRAKOTROKA 3

1 Biochemistry laboratory, University Hospital Center Joseph Ravoahangy Andrianavalona Madagascar.
2 Laboratory, University Hospital Center Andrainjato Fianarantsoa Madagascar.
3 Laboratory of Training and Research in Medical Biology Antananarivo Madagascar.\
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(03), 304–308.
Article DOI: 10.30574/gscbps.2022.19.3.0228
Publication history: 
Received on 08 May 2022; revised on 19 June 2022; accepted on 21 June 2022
 
Abstract: 
Introduction: In Madagascar, the number of diabetic patients registered in the health system is constantly increasing. Access to glycated haemoglobin (HbA1c) testing remains limited. The objective of this study was to describe the prescription of HbA1c dosage seen in the biochemistry laboratory of the University Hospital Centre - Joseph Ravoahangy Andrianavalona (CHU-JRA).
Materials and methods: This is a retrospective, descriptive and analytical study conducted in the Biochemistry laboratory of CHU-JRA, carried out from March 1 to April 30, 2022 on the analysis request forms of patients who had an HbA1c dosage.
Results: A total of 327 HbA1c assays were selected. The mean age was 57 years with a sex ratio of 0.9. The age group 40-60 years was the most represented (44%). Covid-19 was the most common clinical information (35.5%) followed by warning signs and/or risk factors for diabetes (33.3%). HbA1c was in the normal range in 30.6% of cases. Approximately 51.7% of the HbA1c tests were associated with a fasting blood glucose test. Simultaneous elevation of blood glucose and HbA1c was observed in 26.6% of cases. On the other hand, 44.4% of the cases had an HbA1c level <6% associated with a normal blood glucose level.
Conclusion: The prescription of HbA1c remains low in the laboratory. The majority of results show poor glycaemic control. This study argues in favour of raising awareness among practitioners of the importance of HbA1c testing in the optimal management of diabetes.
 
Keywords: 
Biochemistry Laboratory; CHU JRA; Glycemia; HbA1c
 
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