Human Papillomavirus genotypes in cervical intraepithelial lesions among women at two referral centers in Brazil
1 Department of Oncology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.
2 Department of Research, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.
3 Associate Researcher, Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil.
4 Department of Epidemiology, Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 14(03), 082-089.
Article DOI: 10.30574/gscbps.2021.14.3.0064
Publication history:
Received on 21 January 2021; revised on 24 February 2021; accepted on 28 February 2021
Abstract:
This study aimed to describe Human Papilloma Virus (HPV) genotypes and women with cervical intraepithelial neoplasia (CIN) sociodemographic characteristics at the oncology reference centers. A secondary data of 325 records on women with CIN were analyzed from a cohort study database conducted in two public institutions in the oncological service in the Northeast of Brazil, from July 2014 to February 2016. The HPV genotype analysis was carried out on 142 through viral DNA sequence after amplifying PCR technique and compared the sequences identified in the GenBank databases. The women were predominantly 25 to 39 years old. The 325 biopsies revealed 17.6% low-grade of cervical intraepithelial lesion (CIN1) and 82.4% high-grade of cervical intraepithelial lesion (CIN2 or CIN3). Among the 142 HPV genotypes the most prevalent was HPV-16 (51.7%), followed by HPV-35 (6.9%) and HPV-45 (6.2%). HPV-18 was in only 2.1%. There was an association between HPV-16 and high-grade lesions (CIN2 or CIN3) (p=0.008). Although HPV-16 was the predominant genotype in cervical intraepithelial lesions, especially high-grade lesions (CIN2 or CIN3), HPV-35 was the second most frequent in high-grade lesions in this population. This suggests that other HPVs may be as prevalent as those commonly known in some regions.
Keywords:
HPV; CIN; HSIL; LSIL; Papillomaviridae; Cervical Intraepithelial Neoplasia; Uterine Cervical Neoplasms.
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Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
