The influence of ethanol extract of dayak onion (Eleutherine palmifolia) on the number of Leydig cells and seminiferous tubules diameter in mice (Mus musculus) exposed to monosodium glutamate
Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 26(02), 001–009.
Article DOI: 10.30574/gscbps.2024.26.2.0042
Publication history:
Received on 13 December 2023; revised on 31 January 2024; accepted on 02 February 2024
Abstract:
Objective: This study aimed to investigate the preventive effect of ethanol extract from dayak onion (Eleutherine palmifolia) on the number of Leydig cells and the diameter of seminiferous tubules in mice (Mus musculus) exposed to monosodium glutamate (MSG).
Method: A total of 25 mice were divided into 5 groups. Group C- received only 0.5% CMC-Na. Group C+ was given 0.5% CMC-Na and 4 mg/gBW/day of MSG. Groups T1, T2, and T3 were administered dayak onion (Eleutherine palmifolia) ethanol extract at doses of 30, 60, and 120 mg/kgBW/day, respectively, along with 4 mg/gBW/day of MSG. All treatments were administered orally for 52 days.
Result: The results indicated that MSG exposure resulted in a significant decrease in the number of Leydig cells and the diameter of seminiferous tubules in the C+ group compared to the C- group (p < 0.05). Administration of dayak onion (Eleutherine palmifolia) ethanol extract at doses of 30 (T1), 60 (T2), and 120 mg (T3) per kg BW showed similar results (p>0.05) to those of the C- group.
Conclusion: In conclusion, the administration of dayak onion (Eleutherine palmifolia) ethanol extract mitigates the harmful effects of MSG on the number of Leydig cells and seminiferous tubules diameter in mice (Mus musculus) as a model. This research shows that Dayak onion (Eleutherine palmifolia) plays a role in reproductive health care.
Keywords:
Dayak Onion; MSG; Leydig Cells; Seminiferous Tubules Diameter; Reproductive Health Care
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