An insight to the incidence of acute pancreatitis, and co-morbidity of diabetes in SARS-COV2 infection
1 Department of Environment and Pollution, University of Thi-Qar, Iraq.
2 Department of Soil and Water, University of Thi-Qar, Iraq.
3 Department of Pharmacology, College of medicine, University of Thi-Qar, Iraq.
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(01), 113–137.
Article DOI: 10.30574/gscbps.2022.19.1.0142
Publication history:
Received on 06 March 2022; revised on 09 April 2022; accepted on 11 April 2022
Abstract:
Since the emergence of SARS-COV2 infection, accumulating reports as well as evidences have been reported to the complex disease-disease interactions between this viral infection and the pre-existing diabetes co-morbidity. Hyperglycemia accompanied the onset of infection is repeatedly reported to be associated with the disease severity, prognosis and mortality rate elevation. Various mechanism has been speculated to lay behind the reported hyperglycemia including direct pancreatic tissues tropism besides the indirect cytokine storm overwhelming inflammatory immune response. In another perspective, other collection of studies has reported and emphasized the involvement of SARS-COV2 infection in the development of acute pancreatitis as one of this infection complications during the onset of infection, hence increasing the morbidity of such infection including the admission of the patients to the intensive care unit. Some have related the diagnosis of acute pancreatitis to the serum amylase and lipase levels manifested with the experienced GI symptoms, while, others consider CT scan images to confirm diagnosis. Finally, some reporters has hypothesized that SARS-COV2 infection may develop autoantibodies that probably precipitate type I diabetes mellitus long after infection. Therefore, due to significance of hyperglycemia/ diabetes to fate / severity of the infection as well as long term complications of SARS-COV2 this survey have covered aspects related to these issues.
Keywords:
SARS-COV2 Infection; Diabetes; Hyperglycemia; Acute Pancreatitis; Co-Morbidity
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