Intrarenal injection of silica mesoporous reduced renal toxicity induced by gentamycin in rats
1 Department of zoology, Faculty of science, Sirte University. Sirte Libya.
2 Department of Zoology. Faculty of Science, Cairo University, Egypt.
3 Faculty of Pharmacy, Cairo University, Egypt.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(01), 061–065.
Article DOI: 10.30574/gscbps.2022.19.1.0138
Publication history:
Received on 01 March 2022; revised on 04 April 2022; accepted on 06 April 2022
Abstract:
Introduction: Mesoporous silica (MS) has recently used in biomedical applications due to its distinctive physicochemical properties.
Purpose: The study aims to investigate the efficacy of MS to reduce renal toxicity induced by gentamicin in rats.
Methods: The rats were randomly divided into three groups (n=6 per group): Control group (injected with 0.9% saline i.p daily for 8 consecutive), Gentamycin (injected with gentamycin, 100 mg/kg bw i.p. for 8 consecutive days) and MS group (after gentamycin injection, rat injected into left kidney with MS; 70 μg/0.5 ml/ rat).
Results: Ms Treatment caused significant decreases in creatinine, urea, uric acid, and MDA while it increased GSH and catalase levels.
Conclusion: Intrarenal injection of MS improved renal function in rats suffering from acute kidney injury.
Keywords:
Acute Kidney Injury; Mesoporous Silica; Intrarenal Injection; Gentamycin
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