Klebsiella pneumoniae, an important Uropathogen: Characteristics and antimicrobial susceptibility pattern at Prof. Dr. I.G.N.G. Ngoerah general hospital, period February – September 2020
Department of Clinical Microbiology, Faculty of Medicine and Health Sciences Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali, Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 24(01), 380–384.
Article DOI: 10.30574/gscbps.2023.24.1.0298
Publication history:
Received on 16 June 2023; revised on 26 July 2023; accepted on 29 July 2023
Abstract:
Background: Klebsiella pneumoniae (K. pneumoniae) caused urinary tract infections (UTIs) are the rise all over the world and have emerged as a significant issue for public health. K. pneumoniae's characteristics as a uropathogen and their antimicrobial susceptibility pattern will be examined in this study at a tertiary care hospital.
Method: The Clinical Microbiology laboratory at Prof. Dr. I. G. N. G. Ngoerah General Hospital was where this descriptive retrospective cross-sectional study was carried out. All urine cultures were included in this study, and Vitek-2 Compact (BioMerieux®) was used to identify and test for bacterial susceptibility. Data were collected over a period February-September 2020.
Result: The results show 60 isolates K. pneumoniae was isolated from urine specimens. This study included outpatients and inpatients of both sex with different age. The male (51.7%) has the highest rate of infection compared to the female (48.3%), with adult patients (76.7%) and child patients (23.3%), whereas Extended-Spectrum β-Lactamase (ESBL) producing K. pneumoniae (53.3%) and non-ESBL (46.7%). The antimicrobial susceptibility test showed that K. pneumoniae mostly sensitive to meropenem (96.7%) and amikacin (93.3%) and resistance to nitrofurantoin (73.3%) and ciprofloxacin (65%).
Conclusion: This study found that the percentage of ESBL producing K. pneumoniae was 53.3%. Antibiotics that are often used for the treatment of UTIs, ciprofloxacin and trimethoprim/sulfamethoxazole, have high resistance rate of 65% and 51.7%, respectively. In addition, Ertapenem, meropenem, and amikacin had the highest antimicrobial sensitivity rates.
Keywords:
Uropathogen; Klebsiella pneumoniae; Susceptibility pattern; Antibiotic resistance
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