Luteolin: A versatile flavonoid for anti-inflammatory, anti-cancer, and neuroprotective therapies
1 Department of Biochemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.
2 Department of Material Science and Nanotechnology, School of Engineering and Natural Sciences, Kadir Has University, Istanbul Turkey.
3 Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
4 Biotechnology Program, Department of Mathematics and Natural Sciences, BRAC University, Dhaka, Bangladesh.
GSC Biological and Pharmaceutical Sciences, 2024, 29(03), 119–137.
Article DOI: 10.30574/gscbps.2024.29.3.0457
Publication history:
Received on 10 November 2024; revised on 09 December 2024; accepted on 12 December 2024
Abstract:
Medicinal plants are the alternate source of medicine that performs dynamic biological functions due to the presence of certain bioactive compounds. This current review has also emphasized progress in the therapeutic effects of luteolin. Epidemiological pieces of evidence recommend that flavonoids may play a significant part in the reduction of chances of persistent illnesses related to a diet regimen that may be plentiful in plant-determined food sources. Luteolin shows particular anti-inflammatory reactions via its effects on fibroblast cell multiplication and immigration as well as anti-carcinogen activities, which may somewhat have been clarified through its antioxidants by free radical scavenging capacity. It is exposed for infiltration into human skins, enabling it an aspirant for avoidance as well as management of skin malignancy. It is also reported for anti-diabetic, and neurodegenerative effects in human beings. Diabetic wounds are prevalent health problems that affected about 16% of individuals with diabetes. Flavonoids are consistent constituents of plants utilized in traditional medication for the treatment of the extensive scope of infections. Luteolin has the capacity to repress angiogenesis, for promotion of apoptotic cell death, to anticipate carcinogenesis in creature models, to decrease tumor development in vivo, and to sensitized cancerous cells to cytotoxic impacts of several anti-cancerous medications endorses that this flavonoid has chemo-preventive and chemo-therapeutic potentials. Inhibition of ros, restraint of topoisomerases i and ii, a decrease of nf-kappa b and ap-1 movement, adjustment of p53, and hindrance of pi3k, stat3, igf1r, and her2 are conceivable processes engaged with the organic exercises of luteolin.
Keywords:
Reactive oxygen species; Nuclear factor-kappa B; Active protein; Insulin-like growth factor 1; Phosphoinositide 3-kinases; Signal transducer and activator of transcription 3
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