Mechanisms of Drug Resistance in Breast Cancer
1 Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Dgo, Mexico.
2 Department of Genetics. Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Dgo., Mexico.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 27(03), 105–111.
Article DOI: 10.30574/gscbps.2024.27.3.0227
Publication history:
Received on 04 May 2024; revised on 11 June 2024; accepted on 13 June 2024
Abstract:
Breast cancer is a complex disease resulting from the interaction between genetic and environmental factors, and addressing them constitutes one of the major challenges in the treatment of this disease. Resistance to therapies represents a significant obstacle to achieving effective results in the treatment of breast cancer, multiple therapeutic approaches are available to address this disease in patients. The majority of breast cancer cases show estrogen receptor (ERα) expression, and treatments targeting this pathway are critical in their approach. However, the emergence of resistance to these treatments is a common problem, leading to cancer recurrence and relapse. This review provides an overview of the mechanisms contributing to drug resistance, highlighting the relevance of epigenetic factors as promising therapeutic targets to address clinical resistance. Furthermore, it emphasizes the importance of further research to find effective strategies that can overcome this resistance and improve treatment outcomes in patients suffering from breast cancer.
Keywords:
Breast Cancer; Resistance; Treatment; Drug; Cancer Stem Cells
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
