Microfluidic organ-on-a-chip models of human lungs and heart: A review
Dr.Rajendra Gode institute of pharmacy Amravati, mardi road Amravati, Maharashtra, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2023, 24(02), 205–214.
Article DOI: 10.30574/gscbps.2023.24.2.0329
Publication history:
Received on 04 July 2023; revised on 12 August 2023; accepted on 14 August 2023
Abstract:
A micro-physiological system is another term for an organ-on-a-chip. Due to the idea's widespread use in drug discovery, precision medicine, and drug screening, interest in it has increased recently. The primary message of this article is to illustrate how artificial drug proof can closely imitate the human body in every regard. Important work for a biomimetic system of physiological organs based on a microfluidic chip using cell biology, engineering, and biomaterials technology. In addition, the use and effectiveness of the gut-on-a-chip, liver-on-a-chip, lung-on-a-chip, and heart-on-a-chip are examined. We have discussed the current status of this project, OOC prospects for the future, and opportunities for microfluidic devices and organs on a chip in this section.
Keywords:
OOC- organ-on-a-chip; ECM- Extracellular matrix; PDMS- polydimethylsiloxane; PMMA- polymethylmethacrylate; cardiomyocytes; PILC- perfusion-incubator-liver-chip; interleukins; LOC- lab-on-a-chip
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
