Muco-adhesive buccal control delivery system
Department of Pharmaceutics, Dr Rajendra Gode College of Pharmacy Amravati, Dist- Amravati (444602) Maharashtra, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 29(03), 157–164.
Article DOI: 10.30574/gscbps.2024.29.3.0462
Publication history:
Received on 26 October 2024; revised on 05 December 2024; accepted on 07 December 2024
Abstract:
Mucoadhesive buccal drug delivery systems have drawn a lot of interest lately because of their potential to improve bioavailability and prolong drug retention at the site of absorption, both of which can lead to improved therapeutic outcomes. The principles of buccal medication administration are examined in this study, with a particular emphasis on mucoadhesion as a crucial mechanism that promotes steady and regulated drug release. The article explores the concepts of designing buccal formulations, such as tablets, films, and patches, as well as the anatomy and permeability of the buccal mucosa. It also discusses several kinds of mucoadhesive polymers. The advantages of buccal medication delivery—such as avoiding hepatic first-pass metabolism and enhancing patient compliance—are thoroughly examined. In addition, difficulties with drug permeability, formulation stability, and patient variability are explored, along with new developments in bioengineering and nanotechnology that are spurring innovation in this area. The analysis closes by outlining potential directions for the future and the contribution of mucoadhesive buccal systems to the creation of more effective and patient-friendly medication delivery techniques.
Keywords:
Buccal Cavity; Films; Mucoadhesive; Future Direction
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
