Multi-layered tablets: A comprehensive review on technologies and research
Department of Pharmaceutics, Raghu College of Pharmacy, Dakamarri, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 29(02), 178–188.
Article DOI: 10.30574/gscbps.2024.29.2.0406
Publication history:
Received on 21 September 2024; revised on 05 November 2024; accepted on 08 November 2024
Abstract:
Multilayered tablets combine two or more active pharmaceutical ingredients for an improved therapeutic effect or to achieve a specific drug release profile. In multi-layered tablets two or more active pharmaceutical ingredients can be combined where one layer or one drug may be for immediate release and the other layer of the drug may be for sustained release of drug i.e., one layer is a loading dose and the other layer may be a maintenance dose. Multilayered tablets can help overcome the drug interactions and the disadvantages of non-linearity associated with diffusion-controlled matrix devices, providing an increased surface area and increasing drug release rate with time. This review article discusses different techniques involved in the preparation of multi-layered tablets along with research on multi-layered tablets.
Keywords:
Multi-layered tablets; Immediate release; Sustained release; Tableting techniques
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
