Natural products with anticonvulsant potentials from Syzygium aromaticum (Myrtaceae)
1 Department of Chemistry, Faculty of Science, University of Buea, P.O. Box 63-Buea, Cameroon.
2 Department of Animal Biology and Conservation, Faculty of Science, University of Buea, P. O. Box 63-Buea, Cameroon.
2 Department of Animal Biology and Conservation, Faculty of Science, University of Buea, P. O. Box 63-Buea, Cameroon.
3 Center for Advanced Materials Characterization in Oregon, University of Oregon, 1443 E, 13th AVE, Eugene, OR 97403, USA.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 22(01), 001-014.
Article DOI: 10.30574/gscbps.2023.22.1.0414
Publication history:
Received on 26 September 2022; revised on 01 November 2022; accepted on 04 November 2022
Abstract:
Chemical investigation of the methanol crude extract of dried flower buds of Syzygium aromaticum (Myrtaceae) resulted in the isolation of seven known compounds; oleanolic acid (1), lignoceric acid (2), β-sitosterol (3), heneicosanoic acid (4), 5-hydroxy-7-methoxy-2-methylchromone (5), 5-hydroxy-7-methoxy-2,8-dimethylchromone (6) and vanillin (7). Their structures were elucidated using one-dimensional NMR spectroscopy and comparison with literature data. The crude extract, and compounds 1-6, revealed significant anticonvulsant activities against seizures induced by picrotoxin, pentylenetetrazole and bicuculline, respectively in mice. Compound 3 produced 100% protection, compound 2, and 5; on the other hand, each offered 83.33%, while the lowest protection came from compounds 1, 4, and 6 (16.66 – 50 00 %). This is the first report on the anticonvulsant activity of these isolated compounds, and the first report on the isolation of compounds 2, 4, 5, 6, and 7 from Syzygium aromaticum.
Keywords:
Syzygium aromaticum; Anticonvulsant; Chemo-convulsants; Mice
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
