An overview of lipid based vesicular systems: stability and regulatory considerations
Department of Pharmaceutics, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Medchal, Hyderabad, Telangana, India.
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 21(03), 053–061.
Article DOI: 10.30574/gscbps.2022.21.3.0458
Publication history:
Received on 28 October 2022; revised on 02 December 2022; accepted on 05 December 2022
Abstract:
Lipid based drug delivery systems are used to encapsulate the active substance within or interior space of the lipid bilayer. The lipid-based drug products are designed to improve the stability in-vivo and pharmacokinetics behavior of active substances. However, understanding of the factors that affect the stability is critical for rationale development of lipid based drug delivery systems with desired pharmacokinetics and bio-distribution. Lyophilization is one primary approach to improve the stability of lipid based systems. The article presents an overview of the characteristics of the lipid based drug delivery systems as drug carriers, particularly in relation to stability, regulatory considerations. Further, the present review emphasizes the formulation problems and marketed formulation of lipid-based systems.
Keywords:
Lipid based drug delivery systems; Lyophilization; Liposomes; Vesicular systems.
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
