Peripheral neuro-regeneration: A narrative review of the mechanism and complications

Vinícius Benatti Freire 1, *, Lívia Ayres Mendes Khair 1, Mário Henrique de Lima Martinelli 1, Lucas Cressoni de Souza 1, Milena Ramos de Souza 1, Thays Illane Ledo de Faria 1, Amanda Gabriela Marangoni de Moraes 1, Steffany Eduarda Barbosa da Silva 1, Nicolas Vitorino Thoröe Scherb 1, Abraão Filipe Nascimento Reis dos Santos 2 and Gabriela Godinho Gutierres 2

1 Nove de Julho University's Department of Medicine, Vergueiro Campus, São Paulo, Brazil.
2 Nove de Julho University's Department of Medicine, Osasco Campus, São Paulo, Brazil.
 
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 20(03), 307–323.
Article DOI: 10.30574/gscbps.2022.20.3.0369
Publication history: 
Received on 17 August 2022; revised on 22 September 2022; accepted on 24 September 2022
 
Abstract: 
Neuroplasticity differs from neuroregeneration, although both phenomena propose functional recovery after injury. The difference between both is evidenced in terms of recovery time, molecular reaction, gene and molecular expression, as well as conceptual. In this paper, we show the process of peripheral neuroregeneration and some differences between the neuroplasticity of the peripheral and central nervous system, as well as some complications of the process of neuroregeneration of the peripheral nervous system. To carry out the work, the PubMed platform was used with two batteries of descriptors to find the articles, in addition to filters that the platform provides for the selection of articles. In addition, some authors found in the platform search suggested the reading of other articles and these were included in this work according to the inclusion and exclusion methods. The process of peripheral neuroregeneration is complex, involving many signaling pathways, inflammatory and cellular response, and gene expression that favor neuroregeneration. It can be concluded that the mechanism of neuroregeneration consists of three main pillars that are pro-regenerative gene expression, inflammatory response, and Schwann cell action. However, it is not a perfect mechanism, and some complications have been evidenced.
 
Keywords: 
Neuroplasticity; Neuroregeneration; Schwann Cells; Gene Expression; Inflammatory Response; Complications
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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