Phytochemical and pharmacological study of Rosa x gallica L. georgian cultivar essential oil production waste

Mariam Puladze 1, Karen Mulkijanyan 2, Natela Gogitidze 2, Marine Sulakvelidze 2, Zhana Novikova 2, Nadezhda Mushkiashvili 2, Malkhaz Getia 3, Michel Frédérich 4, Ange Mouithys-Mickalad 5, Thierry Franck 5 and Lasha Mskhiladze 1, *

1 Direction of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Tbilisi State Medical University, Tbilisi, 0186, Georgia.
2 Department of Preclinical Pharmacological research, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, 0159, Georgia.
3 Department of Pharmaceutical Analysis and Standardisation, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, 0159, Georgia.
4 Laboratory of Pharmacognosy, Department of Pharmacy, University of Liège, Centre Interdisciplinaire de Recherche sur le Medicament, Liège, B-4000, Belgium.
5 Centre for Oxygen Research and Development (CORD), Institute of Chemistry B6a, University of Liège, Sart Tilman, 4000 Liège 1, Belgium.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(03), 213–222.
Article DOI: 10.30574/gscbps.2022.19.3.0242
Publication history: 
Received on 15 May 2022; revised on 16 June 2022; accepted on 18 June 2022
 
Abstract: 
The study aimed to assess chemical composition and pharmacological properties of Rosa x gallica cultivated in Georgia for application in medicine and cosmetology.
The quantitative and qualitative composition of secondary metabolites of the aqueous extract obtained during the production of essential oil of R. gallica (AERGP) was analysed using HPLC analytical methods, and its pharmacological activity was evaluated in in vitro and in vivo experiments.
Five prevalent compounds have been established in AERGP: Glycyrrhetinic acid (0.83%), Hyperoside (1, 08%), Caffeic acid (0, 85%), Quercetin (6, 17%), and Ferulic acid (0, 28%).  Studies of antioxidant activity of AERGP revealed its dose-dependent radical scavenging effect in both ABTS (IC50 20.0 µg/mL), and DPPH (IC50 39.0 µg/mL) assays. AERGP appeared active against Plasmodium falciparum 3D7 strain (IC50 47.2 µg/mL). In in vivo experiments AERGP showed pronounced analgesic (124%) and anti-inflammatory effects (67.58%), as well as a moderate gastroprotective efficacy (28, 9%).
 
Keywords: 
Rosa x Gallica; Flavonoids; Quercetine; Anti-Inflammatory; Analgesic; Antioxidants
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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