Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats

Tsado Amos Ndarubu 1, Onukogu Stella Chiamaka 2, Suleiman Alfa 3, Mustapha Aishatu 4, 5, Osuigwe Ekeoma Chinedu 2, Dannana Luke Wenawo 2, Alawode Rhamatalah Adenike 6, Lawal Bashir 2, * and Berinyuy Bonghan Eustace 7

1 Department of Biological Sciences, Niger State Polytechnic Zungeru, P.M.B 001, Zungeru, Niger State.
2 Department of Biochemistry, Federal University of Technology Minna, P.M.B. 65, Nigeria.
3 Department of Biological Sciences, Federal Polytechnic Bida, Nigeria.
4 Department of Microbiology, Federal University of Technology Minna, P.M.B. 65, Nigeria.
5 Niger State Primary Health Care Development Agency. Station: PHC Tunga, Niger State Nigeria.
6 Forestry research institute of Nigeria-Southern Guinea Research Station, Mokwa, Niger State, Nigeria.
7 Faculty of medicine and biomedical sciences, University of Yaounde 1, Yaounde, Cameroon.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 08(03), 070-078.
Article DOI: 10.30574/gscbps.2019.8.3.01170
Publication history: 
Publication history: Received on 01 September 2019; revised on 05 September 2019; accepted on 10 September 2019
 
Abstract: 
This study investigates the phytochemicals, antidiabetic and hypolipidemic activities of Hibiscus sabdariffa methanol leaves extract in alloxan induced diabetic wistar rat by administering graded oral doses (100, 200 and 400 mg/kg body weight) for 21 days. Results revealed that the methanol leaf extract of Hibiscus sabdariffa contains 51.90±3.89 mg/100g of tannins, 102.56±6.89 mg/100g of saponins, 54.78±3.89 mg/100g of alkaloids, 67.45±3.87 mg/100g of flavonoids and 121.54±5.67 mg/100g of phenols. The extract showed dosed dependent significant (p<0.05) antidiabetic activity with significant improvement in body weight. The extract also resulted in significant (p<0.05) reduction serum cholesterol, triglycerides. LDL-cholesterol level and increase HDL-cholesterol when compared with untreated control. In conclusion, this study demonstrates, for the first time, that Hibiscus sabdariffa is effective in inhibiting hyperglycemia and dyslipidemia in diabetes condition.
Keywords: 
Hibiscus sabdariffa; Phytochemicals; Hyperglycemia; Hyperlipidemia; Diabetes
 
Full text article in PDF: 
 
Copyright information: 
Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

Share this